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Also reported in: ng/L
Your zonulin is in the normal range, consistent with normal gut permeability and intact tight junction function.
No measurable zonulin was detected. Zonulin is a protein that regulates tight junction permeability in the gut. An undetectable level indicates excellent gut barrier integrity.
No action needed. Your gut wall appears to have strong barrier function.
Zonulin undetectable — no zonulin-mediated gut permeability signalYour zonulin is within the normal reference range. This indicates that your gut tight junctions are functioning appropriately and there is no significant zonulin-mediated increase in gut permeability.
No action needed. Continue a gut-supportive diet with adequate fiber and fermented foods.
Zonulin within normal reference range — gut barrier integrity maintainedYour zonulin is in the low-normal range, indicating excellent gut barrier function with minimal permeability.
No action needed.
Zonulin: low-normal — good gut barrier integrityYour zonulin is in the normal range, consistent with normal gut permeability and intact tight junction function.
No specific action required.
Zonulin within reference range — normal gut permeabilityYour zonulin is in the optimal range, reflecting minimal gut permeability and excellent gut barrier integrity.
No action needed.
Zonulin: optimal — minimal gut permeability signalYour zonulin is mildly above the reference range, suggesting early or mild increase in gut permeability. This can occur with gluten intake (particularly in celiac or NCGS), dysbiosis, NSAID use, stress, and certain dietary patterns. Increased gut permeability may allow bacteria and food antigens to reach the bloodstream.
Discuss with your doctor. Consider reducing gluten, addressing dysbiosis, and supporting gut barrier function with probiotics, zinc, and butyrate-producing foods. Retest in 3 months.
Zonulin 22–40 ng/mL — borderline elevated; gut permeability may be increasedYour zonulin is significantly elevated, indicating meaningful gut permeability increase. Increased gut permeability ('leaky gut') allows bacteria, food antigens, and toxins to translocate into the bloodstream, potentially triggering systemic inflammation, food sensitivities, autoimmune activation, and metabolic dysfunction.
Seek functional medicine or gastroenterology evaluation. Test for celiac disease (anti-tTG IgA), assess for dysbiosis, and consider elimination diet. Gut barrier repair protocols using L-glutamine, zinc carnosine, and probiotics may be beneficial under medical guidance.
Zonulin >40 ng/mL — elevated; significant gut barrier dysfunctionYour zonulin is critically elevated, indicating very compromised gut barrier function. This level of permeability may be associated with active celiac disease, noticeable IBD, SIBO, or other serious gut pathology. Systemic consequences of noticeable leaky gut include widespread inflammation, autoimmune activation, and metabolic endotoxemia.
Seek urgent gastroenterology evaluation. Celiac disease, IBD, and SIBO should be actively investigated. This level requires comprehensive gut assessment and targeted therapeutic intervention.
Zonulin >60 ng/mL — critically elevated; noticeable gut permeability dysfunctionUpload your lab report and get your actual values interpreted in plain English — instantly, with no medical training required.