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Also reported in: nmol/L
Dexamethasone is a synthetic steroid that normally suppresses ACTH release, which in turn lowers cortisol. The 8-hour level being below 1.5 µg/dL means the negative feedback loop is working normally. This rules out Cushing's disease.
The adrenal glands responded appropriately to dexamethasone suppression. This is actually a normal finding and rules out Cushing's disease.
No action needed. A strongly suppressed cortisol confirms intact negative feedback.
Canine LDDST 8-hour cortisol: 0.3 µg/dL (Low)Dexamethasone is a synthetic steroid that normally suppresses ACTH release, which in turn lowers cortisol. The 8-hour level being below 1.5 µg/dL means the negative feedback loop is working normally. This rules out Cushing's disease.
No action needed. Your dog has normal adrenal feedback regulation.
Canine LDDST 8-hour cortisol: 1.0 µg/dLIn a normal dog, dexamethasone suppresses cortisol for 8+ hours. If the 8-hour cortisol is above 1.5 µg/dL, the feedback loop is broken, which is the classic finding for hyperadrenocorticism. If the 4-hour sample was suppressed but the 8-hour sample escaped, this suggests pituitary-dependent Cushing's.
Your dog has a positive LDDST result for Cushing's. An abdominal ultrasound will help determine if it's pituitary-dependent or an adrenal tumor. Discuss treatment with trilostane or mitotane with your vet.
Canine LDDST 8-hour cortisol: 2.5 µg/dL (Not Suppressed)Upload your lab report and get your actual values interpreted in plain English — instantly, with no medical training required.