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Also reported in: umol/L
A normal DHEA-S (a partner-hormone to cortisol) level within the reference range indicates adequate adrenal production of this key anti-aging, anti-stress steroid. Normal DHEA-S (a partner-hormone to cortisol) supports sex hormone balance, immune function, brain health, and acts as a natural buffer against the catabolic effects of cortisol excess.
DHEA-S (a partner-hormone to cortisol) is the most abundant circulating steroid hormone and serves as a precursor for sex hormones while having its own direct effects on the brain, immune system, and metabolism. Very low DHEA-S (a partner-hormone to cortisol) indicates noticeable depletion of adrenal reserve — seen in advanced adreduced kidney function, very large aging, prolonged noticeable stress, or chronic glucocorticoid therapy suppressing adrenal function. Very low DHEA-S (a partner-hormone to cortisol) is associated with noticeable fatigue, depression, cognitive decline, and immune failure.
Seek medical evaluation. Adrenal function testing and endocrinology assessment are needed. DHEA replacement therapy under medical supervision may be appropriate.
DHEA-S: {{value}} {{unit}} — very low (ref: {{low}}–{{high}}; critical: <50)Low DHEA-S (a partner-hormone to cortisol) is associated with persistent fatigue, low mood, depression, reduced libido, brain fog, poor immune function, and accelerated aging of the brain and body. DHEA-S (a partner-hormone to cortisol) peaks in the mid-20s and naturally declines with age, but low levels for age are associated with worse cognitive and mental health outcomes. The cortisol-to-DHEA ratio becoming unfavorable drives many stress-related symptoms.
Discuss with your doctor. DHEA supplementation (low dose, 25–50 mg) under medical supervision has evidence for improving mood, fatigue, and cognitive function in deficient individuals.
DHEA-S: {{value}} {{unit}} — low (ref: {{low}}–{{high}})Borderline low DHEA-S (a partner-hormone to cortisol) means the adrenal reserve steroid is in the lower portion of the acceptable range. At this level, the body has less buffer against the catabolic effects of elevated cortisol, and mood-supporting, immune-supporting functions of DHEA are suboptimal. People with borderline-low DHEA-S (a partner-hormone to cortisol) often report mild fatigue and reduced stress tolerance.
Optimize lifestyle factors that support DHEA: regular resistance exercise, quality sleep, stress reduction. Discuss possible supplementation with your doctor if symptoms are present.
DHEA-S: {{value}} {{unit}} — borderline low (ref: {{low}}–{{high}}; borderline: 100–200)A normal DHEA-S (a partner-hormone to cortisol) level within the reference range indicates adequate adrenal production of this key anti-aging, anti-stress steroid. Normal DHEA-S (a partner-hormone to cortisol) supports sex hormone balance, immune function, brain health, and acts as a natural buffer against the catabolic effects of cortisol excess.
Normal result. Continue lifestyle habits that support healthy adrenal function.
DHEA-S: {{value}} {{unit}} — normal (ref: {{low}}–{{high}})An optimal DHEA-S (a partner-hormone to cortisol) between 200 and 400 mcg/dL reflects robust adrenal production of this key hormone. At optimal levels, DHEA-S (a partner-hormone to cortisol) supports mood stability, cognitive performance, immune defense, libido, lean muscle preservation, and provides a healthy counterbalance to cortisol's stress effects. Higher DHEA-S (a partner-hormone to cortisol) within the normal range is associated with better aging and cognitive health outcomes.
Excellent result. Maintain the lifestyle habits supporting healthy adrenal function — particularly adequate sleep, stress management, and regular exercise.
DHEA-S: {{value}} {{unit}} — optimal (ref: 200–400)A borderline elevated DHEA-S (a partner-hormone to cortisol) at the upper end of the normal range is generally not concerning in younger individuals but may warrant investigation if it occurs in post-menopausal women or accompanied by signs of androgen excess (extra body hair, acne, irregular periods). DHEA-S (a partner-hormone to cortisol) at this level is usually benign.
Generally not notable. If accompanied by symptoms of androgen excess, discuss with your doctor.
DHEA-S: {{value}} {{unit}} — borderline elevated (ref: {{low}}–{{high}}; borderline: 400–500)Elevated DHEA-S (a partner-hormone to cortisol) above the normal range can indicate congenital adrenal hyperplasia (CAH), adrenal tumors (adenoma or carcinoma producing excess male-type hormones (androgens)), polycystic ovary syndrome (PCOS) in women, or excess DHEA supplementation. High DHEA-S (a partner-hormone to cortisol) may contribute to androgenic effects — in women this includes extra body hair, acne, menstrual irregularity, and virilization. In men, elevated DHEA-S (a partner-hormone to cortisol) may be less symptomatic but can affect hormonal balance.
Discuss with your doctor. Evaluation for adrenal tumor, CAH, or PCOS may be needed. Review any DHEA supplements you may be taking.
DHEA-S: {{value}} {{unit}} — elevated (ref: {{low}}–{{high}}; elevated: >450)Very high DHEA-S (a partner-hormone to cortisol) above 700 mcg/dL is a major finding that raises significant concern for an adrenal androgen-secreting tumor (adrenal adenoma or carcinoma) or noticeable congenital adrenal hyperplasia. These levels are not achievable through diet or supplementation alone and require imaging and endocrinological evaluation.
Seek endocrinology evaluation urgently. Adrenal imaging (CT or MRI) and comprehensive hormone panel are needed to rule out adrenal tumor.
DHEA-S: {{value}} {{unit}} — very high (ref: {{low}}–{{high}}; critical: >700)Upload your lab report and get your actual values interpreted in plain English — instantly, with no medical training required.