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Also reported in: nmol/L
Your midnight cortisol is within the normal range. This is a reassuring result for Cushing's syndrome screening.
Your midnight cortisol is undetectable, reflecting the normal physiological nadir of the Your brain–adrenal stress system (the HPA axis). Cortisol should be at its lowest between midnight and early morning as part of the healthy diurnal rhythm. An undetectable midnight cortisol is the ideal result.
No action needed. Excellent HPA rhythm.
Midnight cortisol undetectable — normal physiological nadir; optimal HPA rhythmYour midnight cortisol is within the normal physiological nadir range. This is the expected and reassuring result, indicating normal Your brain–adrenal stress system (the HPA axis) function with appropriate nocturnal cortisol suppression.
No action needed.
Midnight cortisol within normal range — normal physiological nadir; no nocturnal hypercortisolismYour midnight cortisol is in the low-normal range, reflecting appropriate Your brain–adrenal stress system (the HPA axis) suppression during the night.
No action needed.
Midnight cortisol: low-normal — normal nocturnal suppressionYour midnight cortisol is within the normal range. This is a reassuring result for Cushing's syndrome screening.
No specific action required.
Midnight cortisol within normal range — acceptable nocturnal cortisol levelYour midnight cortisol is in the optimal range, reflecting ideal Your brain–adrenal stress system (the HPA axis) rhythm with excellent nocturnal suppression.
No action needed.
Midnight cortisol: optimal — ideal nocturnal cortisol suppressionYour midnight cortisol is above the normal nadir. Elevated midnight cortisol is a sensitive screening indicator for Cushing's syndrome, where loss of the normal cortisol diurnal rhythm is one of the earliest signs. It is also elevated in people experiencing chronic stress, depression, alcoholism, and obesity.
Discuss with your hormone specialist. Late-night salivary cortisol testing (two separate samples) and overnight dexamethasone suppression testing are the next steps for Cushing's syndrome evaluation.
Midnight cortisol 1.8–4.0 mcg/dL — elevated; Cushing's syndrome screening indicatedYour midnight cortisol is significantly elevated. Loss of the normal nighttime cortisol nadir is a hallmark of Cushing's syndrome and Your brain–adrenal stress system (the HPA axis) dysregulation. Chronically elevated nighttime cortisol disrupts sleep architecture, promotes insulin resistance, and accelerates aging.
Seek endocrinology evaluation. Cushing's syndrome confirmation testing (late-night salivary cortisol, 24-hour urine free cortisol, dexamethasone suppression testing) and imaging should be arranged.
Midnight cortisol >4.0 mcg/dL — significantly elevated; loss of diurnal rhythm; Cushing's syndrome likelyYour midnight cortisol is critically elevated. At this level, active Cushing's syndrome is strongly supported. Untreated Cushing's syndrome causes progressive metabolic, cardiovascular, bone, and psychiatric damage.
Seek urgent endocrinology evaluation. Comprehensive Cushing's syndrome assessment and pituitary/adrenal imaging should be arranged without delay. Treatment planning depends on the source of excess cortisol.
Midnight cortisol >7.5 mcg/dL — critically elevated; active Cushing's syndrome diagnosis strongly supportedUpload your lab report and get your actual values interpreted in plain English — instantly, with no medical training required.