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Also reported in: U/mL
Your CH50 is within the normal reference range. This indicates intact classical pathway complement function.
Your total hemolytic complement (CH50) is critically low. Very low CH50 indicates either a complete absence of one or more complement proteins (hereditary complement deficiency) or massive complement consumption from active immune complex disease (noticeable lupus, noticeable vasculitis). Complete complement component deficiencies (especially C3, C5–C9 and properdin) dramatically increase susceptibility to Neisseria infections.
Seek urgent immunology or rheumatology evaluation. Testing of individual complement components (C1q, C3, C4, C5-C9) is needed. Infectious disease assessment for Neisseria vulnerability and vaccination are important.
Total complement CH50 critically low — noticeable complement deficiency or massive consumptionYour CH50 is below the reference range. Low total complement indicates either consumption by immune complex disease (lupus, cryoglobulinemia, post-infectious glomerulonephritis) or a genetic partial deficiency of complement components. Low CH50 is a classic feature of active lupus flare.
Discuss with your doctor or rheumatologist. Individual complement component testing (C3, C4) and autoimmune panel review are needed. If autoimmune disease is present, this may signal active disease requiring treatment.
Total complement CH50 below reference range — complement consumption or partial deficiencyYour CH50 is at the lower end of normal. This may reflect mild complement consumption from low-level immune complex disease or a heterozygous complement gene variant.
Monitor in context of autoimmune test results and symptoms. Repeat testing and individual component analysis if concerning.
Total complement CH50: low-normal — borderline complement activityYour CH50 is within the normal reference range. This indicates intact classical pathway complement function.
No specific action required.
Total complement CH50 within reference range — normal complement activityYour CH50 is in the optimal range, reflecting full complement system function.
No action needed.
Total complement CH50: optimal — excellent complement functionYour CH50 is mildly above the reference range. Complement components are acute phase reactants and can rise modestly with infection and inflammation. This is generally not a clinical concern.
No specific action required. Retest if inflammatory symptoms persist.
Total complement CH50 above reference range — possible acute phase elevationYour CH50 is significantly elevated, suggesting an active inflammatory or infectious process stimulating complement synthesis.
Discuss with your doctor if accompanied by other signs of illness.
Total complement CH50 significantly elevated — marked acute phase responseYour CH50 is markedly elevated, suggesting a noticeable acute phase response from major infection, noticeable inflammatory disease, or other significant pathology.
Seek medical evaluation to identify the underlying cause.
Total complement CH50 markedly elevated — noticeable acute inflammatory stateUpload your lab report and get your actual values interpreted in plain English — instantly, with no medical training required.