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Also reported in: g/L
Your C4 is within the normal reference range. This is a reassuring result indicating no significant immune complex-mediated complement consumption.
Your C4 complement is very low. noticeable C4 depletion is a hallmark of active lupus, urticarial vasculitis, and cryoglobulinemia. C4 is particularly sensitive to consumption in immune complex-mediated diseases. C4A null gene variants (common in lupus patients) can also contribute to constitutional C4 deficiency.
Seek urgent medical evaluation. This level typically indicates active autoimmune disease requiring immediate specialist assessment and possible treatment adjustment.
Complement C4 very low (<8 mg/dL) — noticeable C4 consumption; active autoimmune diseaseYour C4 is below the normal reference range. Low C4 occurs in active lupus, hereditary angioedema, and in individuals with C4A or C4B null gene variants (which are particularly common in SLE patients). Low C4 alongside high anti-dsDNA is a classic pattern for lupus flare.
Discuss with your doctor or rheumatologist. Genetic C4 typing may be relevant. In lupus patients, this may signal increasing disease activity.
Complement C4 low (<16 mg/dL) — complement consumption or C4 null allelesYour C4 is at the lower end of normal. This may reflect mild complement consumption, a C4 null allele variant, or early autoimmune activation.
Monitor in context of other autoimmune markers. Discuss with your doctor if you have autoimmune symptoms.
Complement C4: low-normal — borderline C4 statusYour C4 is within the normal reference range. This is a reassuring result indicating no significant immune complex-mediated complement consumption.
No specific action required.
Complement C4 within reference range — normal C4 levelYour C4 is in the optimal range, indicating excellent complement function and no active consumption.
No action needed.
Complement C4: optimal — excellent C4 statusYour C4 is mildly above the reference range. C4 can rise modestly with acute inflammation and infection as part of the acute phase response. This is generally not clinically concerning in isolation.
No specific action required. Retest if inflammatory symptoms persist.
Complement C4 above reference range — acute phase reaction or elevated synthesisYour C4 is noticeably elevated, suggesting an active inflammatory or infectious process stimulating complement synthesis. This is less clinically significant than low C4 in the autoimmune context.
Discuss with your doctor if accompanied by other signs of illness.
Complement C4 elevated — significant acute phase responseYour C4 is markedly elevated, suggesting a strong acute phase response. This can occur with noticeable infection, major tissue injury, or certain malignancies.
Seek medical evaluation to identify the underlying cause of this strong inflammatory signal.
Complement C4 markedly elevated — noticeable acute inflammatory responseUpload your lab report and get your actual values interpreted in plain English — instantly, with no medical training required.