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Also reported in: U/mL
Your anti-Sm is negative, which is the normal result. Anti-Sm is highly specific for SLE when positive but is only present in a minority of SLE patients.
No anti-Smith antibodies were detected. Anti-Sm is one of the most specific autoantibodies for SLE, present in 25–30% of lupus patients. A negative result is reassuring.
No action needed.
Anti-Sm: negative — no anti-Smith antibodies detectedYour anti-Sm is negative and within the normal reference range. This does not rule out lupus as anti-Sm is only positive in a minority of SLE patients, but it reduces the specificity of any lupus diagnosis.
No action needed.
Anti-Sm: negative — within reference rangeYour anti-Sm is at the low-negative range with no clinically significant antibody. This is a reassuring baseline.
No action needed.
Anti-Sm: negative/low — no clinically significant antibodyYour anti-Sm is negative, which is the normal result. Anti-Sm is highly specific for SLE when positive but is only present in a minority of SLE patients.
No specific action required.
Anti-Sm: negative — normal baselineYour anti-Sm is negative, which is the optimal result. This is a favorable finding in the context of lupus surveillance.
No action needed.
Anti-Sm: negative — optimal baseline for lupus surveillanceYour anti-Sm is in the borderline-positive range. This equivocal result warrants repeat testing and clinical correlation. Anti-Sm is highly specific for SLE when clearly positive, so a borderline result needs clarification.
Repeat testing in 4–6 weeks. Discuss with your rheumatologist and interpret alongside ANA and anti-dsDNA results.
Anti-Sm: borderline positive — equivocal result; repeat testing recommendedYour anti-Sm is positive. Anti-Smith is one of the most specific markers for SLE with specificity greater than 99%. A positive anti-Sm result, especially in the context of a positive ANA, constitutes strong evidence for SLE diagnosis. It is included in the ACR/EULAR SLE classification criteria.
Seek rheumatology referral. This result in the right clinical context is highly consistent with SLE and warrants comprehensive disease evaluation and treatment planning.
Anti-Sm: positive — highly specific for systemic lupus erythematosusYour anti-Sm is strongly positive, which in the right clinical context is nearly consistent with SLE. This level requires comprehensive evaluation for multi-organ involvement including kidneys, blood, skin, joints, and the nervous system.
Seek urgent rheumatology evaluation. Complete organ function assessment and initiation of appropriate immunosuppressive treatment planning are needed.
Anti-Sm: strongly positive — SLE diagnosis highly confirmed; disease evaluation requiredUpload your lab report and get your actual values interpreted in plain English — instantly, with no medical training required.