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Also reported in: titer
Your anti-centromere is negative. This is the normal finding for CREST and limited scleroderma surveillance.
No anti-centromere antibodies were detected. Anti-centromere antibodies are the primary marker for limited cutaneous systemic sclerosis (lcSSc) and CREST syndrome. A negative result makes these conditions less likely.
No action needed.
Anti-centromere: negative — no anti-centromere antibodies detectedYour anti-centromere antibody is negative and within the normal range. This is a reassuring result for limited scleroderma and CREST syndrome surveillance.
No action needed.
Anti-centromere: negative — within reference rangeYour anti-centromere is at a low-negative level with no clinically significant antibody.
No action needed.
Anti-centromere: low-negative — no significant antibodyYour anti-centromere is negative. This is the normal finding for CREST and limited scleroderma surveillance.
No specific action required.
Anti-centromere: negative — normal baselineYour anti-centromere is negative, which is the optimal result. Absence of this antibody makes limited systemic sclerosis and CREST syndrome much less likely.
No action needed.
Anti-centromere: negative — optimal baselineYour anti-centromere is in the borderline-positive range. This equivocal result warrants clinical evaluation for features of CREST syndrome including calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias.
Discuss with your doctor. Rheumatology referral and repeat testing are recommended.
Anti-centromere: borderline positive — equivocal; follow-up neededYour anti-centromere antibody is positive. This is found in 70–80% of patients with limited cutaneous systemic sclerosis (lcSSc/CREST syndrome). These patients tend to have a more indolent disease course but are at risk for pulmonary arterial hypertension and primary biliary cholangitis.
Seek rheumatology referral. Echocardiogram for pulmonary hypertension screening, pulmonary function tests, and liver function tests are important baseline evaluations.
Anti-centromere: positive — limited cutaneous systemic sclerosis / CREST syndrome strongly associatedYour anti-centromere is strongly positive, associated with active limited scleroderma and increased risk of pulmonary arterial hypertension. High-titer anti-centromere warrants proactive monitoring for this serious complication.
Seek urgent rheumatology evaluation. Pulmonary hypertension screening with echocardiography and 6-minute walk test should be arranged promptly.
Anti-centromere: strongly positive — active CREST syndrome or lcSSc; pulmonary hypertension risk elevatedUpload your lab report and get your actual values interpreted in plain English — instantly, with no medical training required.