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Also reported in: nmol/L
A normal value suggests the adrenal and gonadal androgen pathways are operating where we'd expect for your age and sex. It's one of the background checks used when investigating androgen-related issues (acne, extra body hair, irregular cycles, PCOS workup); a normal reading helps narrow where to look next but rarely changes the plan on its own.
Androstenedione is an intermediate androgen — a precursor that the adrenal glands and gonads convert to more active hormones like testosterone and estradiol. A low value can reflect adreduced kidney function, ongoing corticosteroid use (which suppresses adrenal androgen production), opioid use (which suppresses the hypothalamic–pituitary–gonadal axis), or simply reduced gonadal activity — including the natural decline after menopause. In isolation, a low androstenedione rarely drives a diagnosis; it's most useful alongside DHEA-S (a partner-hormone to cortisol), cortisol, and testosterone to see whether the whole adrenal-androgen pathway is quiet.
If you're on chronic steroids or opioids, this is expected and usually doesn't need intervention unless you have symptoms (persistent fatigue, low libido, poor recovery). If the low reading is unexplained, pair with a morning cortisol, DHEA-S (a partner-hormone to cortisol), and total testosterone and discuss with your doctor.
Androstenedione: {{value}} {{unit}} — lowA normal value suggests the adrenal and gonadal androgen pathways are operating where we'd expect for your age and sex. It's one of the background checks used when investigating androgen-related issues (acne, extra body hair, irregular cycles, PCOS workup); a normal reading helps narrow where to look next but rarely changes the plan on its own.
No action needed on this value.
Androstenedione: {{value}} {{unit}} — normalElevated androstenedione in women most commonly points toward polycystic ovary syndrome (PCOS), where the ovaries overproduce male-type hormones (androgens). Other may contribute to include non-classic congenital adrenal hyperplasia (CAH), where an enzyme deficiency pushes steroid synthesis toward male-type hormones (androgens); rarer adrenal or ovarian tumors; and, in athletes, use of androstenedione supplements or other anabolic compounds. In men, an isolated high androstenedione is less common and usually points to adrenal pathology or supplement use. The key next step is to distinguish adrenal from gonadal source, and mild from noticeable elevation.
Pair with total testosterone, free testosterone, DHEA-S (a partner-hormone to cortisol), and 17-OH progesterone — that panel almost always clarifies the source. If elevated with symptoms of androgen excess (acne, extra body hair, cycle irregularity), this warrants an endocrinology conversation. If you're taking a supplement marketed for energy, libido, or "test boost," stop it and re-test — most cause real reading shifts.
Androstenedione: {{value}} {{unit}} — elevatedUpload your lab report and get your actual values interpreted in plain English — instantly, with no medical training required.